金汉永，国产自拍
，副教授，药学博士，博士生导师。2015年获得韩国车医学大学药学博士学位，现就职于国产自拍
临床药学与药理系。主要从事分子细胞生物学、药理与毒理学研究。近5年主持多项课题，包括国家自然科学基金项目1项，吉林省科技厅项目1项，吉林省教育厅项目1项等。2021年聘为国产自拍
“青年图们江学者A类”，2023年入选吉林省高层次D类人才。已发表相关领域SCI论文27篇。
【联系方式】
0433-2734008；E-mail: [email protected]
【研究方向】
主要从事分子细胞生物学、药理与毒理学及跨学科研究
【承担科研项目】
（1）地区基金项目，2023.01.01-2026.12.31，“鉴定FOXL2/p53介导的抑制卵巢颗粒细胞瘤转移的调控网络”，33万，主持人；
（2）吉林省自然科学基金项目，2022.07.01-2025.06.30，“AP5M1在大肠癌的生物学功能及调控机制研究”，10万，主持人；
（3）横向课题项目，2023.07.01-2024.11.30，15万，主持人；
（4）Fundamental research program（韩国国家研究基金会），2019.06.01-2022.02.28，“Identification of pathophysiological mechanisms of gastric cancer development and progress”，75万，主持人；
（5）General research program（韩国国家研究基金会），2016.11.01-2019.10.31，“Studies on the elucidation of function and signa ling pathway by identification of GBP2 interactome in myeloid leukemia”，82万，主持人。
【主要发表论文】
1. Hanyong Jin*, Ji-Hyun Yeom*, Eunkyoung Shin*, Yoonjie Ha*, Haifeng Liu*, Daeyoung Kim*, Minju Joo*, Yong-Hak Kim*, Hak Kyun Kim*, Minkyung Ryu*, Hong-Man Kim* , Jeongkyu Kim, Keun P Kim, Yoonsoo Hahn, Jeehyeon Bae#, Kangseok Lee#. 5'-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response. Nature Communications (2024). [SCI一区, Impact factor: 14.70]
2. Zhenhua Li*, Zhuohua Cao*, Fangmei Chen*,Bin Li#, Hanyong Jin#. Lutein inhibits glutamate-induced apoptosis in HT22 cells via the Nrf2/HO-1 signaling pathway. Frontiers in Neuroscience (2023). [SCI三区, Impact factor:3.20]
3.Ji-Hyun Yeom*, Eunkyoung Shin*, Hanyong Jin*, Haifeng Liu, Yongyang Luo, Youngwoo Nam, Minkyung Ryu, Wooseok Song, Heeyoun Chi, Jeongkyu Kim, Kangseok Lee#, Jeehyeon Bae#.Aptamer-conjugated gold nanoparticles platform as the intracellular delivery of antibodies for cancer therapy. Journal of Industrial and Engineering Chemistry (2023). [SCI三区, Impact factor: 6.10]
4.Tae-Il Kim*, Siyoung Cho*, Hanyong Jin, Jeehyeon Bae, Chanhee Park#, Youngmi Kim#.Activatable Fluorescent Probes Targeting Urokinase-Type Plasminogen Activator Receptor on the Cell Membrane. Chemistry (2023). [SCI二区, Impact factor: 4.30]
5.Yuri Choi*, Yongyang Luo*, Seunghwa Lee, Hanyong Jin, Hye-Jin Yoon, Yoonsoo Hahn, Jeehyeon Bae2# and Hyung Ho Lee#. FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Research (2022). [SCI一区, Impact factor: 19.16]
6. Hwanhui Lee,Yeo-Jung Kwon,Hanyong Jin,Heifeng Liu,Wonku Kang,Young-Jin Chun,Jeehyeon Bae,Hyung-Kyoon Choi. Anticancer activity and metabolic profile alterations by ortho-topolin riboside in in vitro and in vivo models of non-small cell lung cancer. FASEB Journal (2022). [SCI二区, Impact factor: 5.191]
7. Haifeng Liu, Hanyong Jin, Guenhwi Kim, Jeehyeon Bae. A low dose of bisphenol A stimulates estradiol production by regulating β-catenin-FOXL2-CYP19A1 pathway in human ovarian granulosa cells. Biochemical and Biophysical Research Communications (2021). [SCI三区, Impact factor: 3.575]
8. Heayyean Lee, Hwanhui Lee, Myeongsun Kim, Ji Young Park, Hanyong Jin, Kyungsoo Oh, Jeehyeon Bae, Young Yang*, Hyung-Kyoon Choi*. Integrative metabolomic and lipidomic profiling of lung squamous cell carcinoma for characterization of metabolites and intact lipid species related to the metastatic potential. Cancers (2021). [SCI二区, Impact factor: 6.639]
9. Yongyang Luo*, Hanyong Jin*, Je-Hyeong Kim, Jeehyeon Bae. Guanylate binding proteins induce apoptosis of leukemia cells by regulating MCL-1 and BAK. Oncogenesis (2021)[SCI二区, Impact factor: 7.485] [*Co-first author]
10. Eunkyoung Shin, Hanyong Jin, Dae-Shik Suh, Yongyang Luo, Hye-Jeong Ha, Tae Heon Kim, Yoonsoo Hahn, Seogang Hyun, Kangseok Lee. Response to Veitia et al.(Correspondence) The EMBO Journal (2021). [SCI一区, Impact factor: 11.598]
11. Eunkyoung Shin*, Hanyong Jin*, Dae-Shik Suh*, Yongyang Luo, Hye-Jeong Ha, Tae Heon Kim, Yoonsoo Hahn, Seogang Hyun, Kangseok Lee, and Jeehyeon Bae. An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2. The EMBO Journal (2020). [SCI一区, Impact factor: 11.598]
12. Junho Ahn, Hanyong Jin, Jaehyeon Park, Boeun Lee, Mirae Ok, Ji Ha Lee, Jeehyeon Bae, Jong Hwa Jung. Coassembled Nanoparticles Composed of Functionalized Mesoporous Silica and Pillar[5]arene-Appended Gold Nanoparticles as Mitochondrial-Selective Dual-Drug Carriers. Particle & Particle Systems Characterization (2020). [SCIE二区, Impact factor: 3.310]
13. Jin H*, Lee B*, Luo Y, Choi Y, Choi EH, Jin H, Kim KB, Seo SB, Kim YH, Lee HH, Kim KP, Lee K, Bae J. FOXL2 Directs DNA Double-strand Break Repair Pathways by Differentially Interacting with Ku. Nature Communications (2020). [SCI一区, Impact factor: 14.919]
14. Sungjin Jeon*, Tae-Il Kim*, Hanyong Jin*, Jeehyeon Bae, Jean Bouffard, and Youngmi Kim. Amine-Reactive Activated Esters of meso-CarboxyBODIPY: Fluorogenic Assays and Labeling of Amines, Amino Acids, and Proteins. Journal of the American Chemical Society (2020). [SCI一区, Impact factor: 15.419]
15. Won M, Luo Y, Lee DH, Shin E, Suh DS, Kim TH, Jin H#, Bae J#. BAX is an essential key mediator of AP5M1-induced apoptosis in cervical carcinoma cells. Biochemical and Biophysical Research Communications (2019). [SCI三区, Impact factor: 3.575]
16. Kim HY, Jin H, Bae J, Choi HK. Metabolic and lipidomic investigation of the antiproliferative effects of coronatine against human melanoma cells. Scientific Reports (2019) [SCI三区, Impact factor: 4.379]
17. Ahn J, Lee B, Choi Y, Jin H, Lim NY, Park J, Kim JH, Bae J, Jung JH. Non-peptidic guanidinium-functionalized silica nanoparticles as selective mitochondria-targeting drug nanocarriers. Journal of Materials Chemistry B (2018) [SCI二区, Impact factor: 6.331]
18. Suh DS, Park SE, Jin H, Lee K, Bae J. LRIG2 is a growth suppressor of Hec-1A and Ishikawa endometrial adenocarcinoma cells by regulating PI3K/AKT- and EGFR-mediated apoptosis and cell-cycle. Oncogenesis (2018). [SCI二区, Impact factor: 7.485]
19. Lee JH, Kim KY, Jin H, Baek YE, Choi Y, Jung SH, Lee SS, Bae J, Jung JH. Self-Assembled Coumarin Nanoparticle in Aqueous Solution as Selective Mitochondrial-Targeting Drug Delivery System. ACS Applied Materials & Interfaces (2018). [SCI一区, Impact factor: 9.229]
20. Kim TI, Jin H, Bae J, Kim Y. Excimer Emission-Based Fluorescent Probe Targeting Caspase-3. Analytical Chemistry (2017). [SCI一区, Impact factor: 6.986]
21. Ka Young Kim*, Hanyong Jin*, Jaehyeon Park, Sung Ho Jung, Ji Ha Lee, Hyesong Park, Sung Kuk Kim, Jeehyeon Bae, Jong Hwa Jung. Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery. Nano Research (2017). [SCI一区, Impact factor: 8.897]
22. Kim HY, Lee H, Kim SH, Jin H, Bae J, Choi HK. Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling. Scientific Reports (2017). [SCI三区, Impact factor: 4.379]
23. Jin H*, Won M*, Shin E, Kim HM, Lee K, Bae J. EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells. Biochemical and Biophysical Research Communications (2016). [SCI三区, Impact factor: 3.575, citation: 9]
24. Jin H*, Won M*, Park SE, Lee S, Park M, Bae J. FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells. PLoS One (2016). [SCI三区, Impact factor: 3.240]
25. Jin H, Lee K, Kim YH, Oh HK, Maeng YI, Kim TH, Suh DS, Bae J. Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells. Oncogene (2016). [SCI一区, Impact factor: 9.867]
26. Jin H*, Suh DS*, Kim TH, Yeom JH, Lee K, Bae J. IER3 is a crucial mediator of TAp73β-induced apoptosis in cervical cancer and confers etoposide sensitivity. Scientific Reports (2015). [SCI三区, Impact factor: 4.379]
27. Kim WH, Song HO, Jin CM, Hur JM, Lee HS, Jin HY, Kim SY, Park H. The Methanol Extract of Azadirachta indica A. Juss Leaf Protects Mice Against Lethal Endotoxemia and Sepsis. Evid. Based. Complement. Biomolecules & Therapeutics (Seoul) (2012). [SCIE三区, Impact factor: 4.634]
【获奖与荣誉】
（1）国产自拍
图们江学者“青年图们江学者A类”，2021年；
（2）吉林省高层次人才D类，2023年；
（3）第七届全国医药院校药学/中药学专业大学生实验技能展示活动（国家级三等奖-第一指导教师）；
（4）“国产自拍
青年五四奖”，2024年；
（5）“国产自拍
先进个人”，2024年。
